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Thank you from ATLANTIS
Thank you very much for your involvement in the ATLANTIS study.
We have now recruited 463 participants into the study and are starting to analyse all the information we have collected. We are very grateful for your help with this study.
Look out for the upcoming study results here, which we hope to be available from the end of 2023:
We plan to make some resources for people with IBS, outlining what this research means for patients and the NHS. We are looking for people with IBS to help us develop those resources. Please let us know if you would like to get involved (

Thank you again for taking part. Research could not happen without people like you giving their valuable time.


ATLANTIS is a clinical trial testing whether a tablet called amitriptyline helps people with irritable bowel syndrome (IBS).

Our video gives an introduction to the ATLANTIS trial for potential participants. You can also download the video transcript.

Are you eligible to join the ATLANTIS study?

What will happen to me if I take part?

1. Screening Call

To make sure you are suitable to take part, you will have an initial telephone call with a researcher to find out more about you and your IBS.

2. Eligibility Tests

If you are eligible to take part, you may be asked to come into your GP practice and have some blood samples taken.

If you are a woman, able to have children, and are unable to confirm you are not pregnant, you will be provided with a pregnancy test to use at home before going into the study. This is to ensure that it is safe for you to receive amitriptyline in the study.

3. Baseline Questionnaire

You will be asked to complete an online or postal questionnaire about your IBS and how it impacts you. You will then be randomly allocated to amitriptyline or placebo.

4. Drug Treatment

You will be asked to take the study drug for 6 months. After 6 months, you can choose to stop taking the study drug, or take it for a further 6 months.

5. Phone Calls

Once you start taking the study drug, you will receive a telephone call from the researcher after:

  • 1 week
  • 3 weeks
  • 3 months
  • 6 months

This is to give you advice about your study medication and check if there are any problems, as well as to answer any questions you may have.

If you decide to take the study drug for 12 months, the researcher will also call you in month 9.

6. Questionnaires

You will complete an online or postal questionnaire at:

  • 3 months
  • 6 months
  • 12 months

You will also answer a question once a week to let us know if the study drug is helping you. This can be answered online or can be recorded in a paper diary.

7. End of Treatment

You will have a telephone call with the researcher when you finish taking the study drug to check if there are any problems and to answer any questions you may have.

8. Trial Summary

ATLANTIS patient flowchart

Interested in taking part?

If you would like to take part, please check if your GP practice is currently taking part in the trial below. Please keep checking this link as new practices will be added regularly!

Please also give our Participant Information Sheet a read, and contact your local researcher if you would like to take part or if you have any further questions.