What is the ROSETA Optimisation trial?
Some patients with breast cancer struggle to take their medications regularly and may even stop altogether. The ROSETA Optimisation trial is testing how well four ways (called interventions) support women with breast cancer in taking hormone therapy (e.g., Tamoxifen, Raloxifene, Anastrozole, Letrozole, Exemestane). We are testing what, if any, is the best combination of the interventions.
Recruitment to ROSETA has now ended as of 27/02/2026 after reaching our recruitment target
What interventions are you testing?
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SMS text reminders to support taking medication. |
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A leaflet providing information about the medication. |
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A website to provide useful resources for managing side effects of the medication. |
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A skills programme known as Acceptance and Commitment Therapy (ACT) which encourages approaching experiences with openness and awareness, and to support you to engage with your values. This is led by a therapist and involves learning and practising skills at home. |
Who can take part?
ROSETA has now finished recruiting, having exceeded our target of 512 participants.
Who is organising the trial?
The trial is being run by the University of Leeds. The Chief Investigator is Professor Sam Smith, a researcher interested in the factors affecting the use of cancer medicines.
Will I get the results?
You can choose to receive a copy of the results by email at the end of the trial.