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The Method Behind STATIC

The Method

In order to test the aims/goals of STATIC, we are testing two different ways of taking ibrutinib.

Participants of the trial will be randomly assigned to one of two treatment groups:

  1. Pausing Ibrutinib
    Participants in this group take a scheduled break from ibrutinib, and only restart if their CLL gets worse. If restarting ibrutinib controls the CLL again, participants will take another break from treatment.
  2. Continuous Ibrutinib
    Participants in this group will take ibrutinib every day. Participants will continue ibrutinib without a break as long as they are benefitting from it.