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The Method Behind STATIC

The Method

In order to test the aims/goals of STATIC, we are testing two different ways of taking ibrutinib. Participants of the trial will be randomly assigned to one of two treatment groups:

  • 1. Pausing Ibrutinib
    Participants in this group take a scheduled break from ibrutinib, and only restart if their CLL gets worse. If restarting ibrutinib controls the CLL again, participants will be able to take another break from treatment.
  • 2. Continuous Ibrutinib
    Participants in this group continue to take ibrutinib every day.

Participants will continue ibrutinib without a break as long as they are benefitting from it.