ALPHA: Comparing Treatments for Severe Chronic Hand Eczema

As restrictions across the UK are being lifted some of our hospitals are now able to enrol new patients onto the study, please check the ‘participating centres’ list on our ‘more information’ tab.

If your chosen participating centre is still unable to enrol new patients onto the trial we are accepting expressions of interest, however it will be unlikely that we can refer you straight away and there may be a delay in responding to you. If you chose to submit your expression of interest today, we will be in touch once your chosen hospital has confirmed they are able to accept new patients onto the study.

Thank you for your understanding, kind regards the ALPHA team.

ALitretinoin versus PUVA in severe chronic HAnd eczema trial

The ALPHA trial compares Alitretinoin and PUVA therapy in patients aged 18 years and over with severe hand eczema which is not controlled on a daily (regular) basis with prescription steroid creams. This is to find out which is the most effective treatment:


Image of psoralen soak
Hands are soaked in psoralen

Image of ultraviolet light exposure
Hands are exposed to UV light


Image of Alitretinoin tablets

Image of Alitretinoin treatment
Taken once a

Both are equally used by doctors in standard clinical practice, but there is no clear evidence indicating which is most effective in treating which type of hand eczema.

BBC Look North (Yorkshire) features Dr Miriam Wittmann discussing the ALPHA trial – click the link to watch the full programme. Here’s a shortened version of the video on the BBC Look North face book page.