The Trial

MODULATE (Management of diarrhoea in ulcerative colitis: A multi-arm, multi-stage trial of low FODMAP diet, amitriptyline, ondansetron, or loperamide) is a clinical trial that aims to identify effective treatments for ongoing diarrhoea in people with stable ulcerative colitis.

More Information

The MODULATE study will incorporate 5 arms; a control group, 3 drug arms (Amitriptyline, Ondansetron and Loperamide) and a dietary arm (the Low FODMAP diet). Each arm is explained further within a set of documents that can be accessed here.

For Participants

A self-screening tool is available to check initial eligibility of ulcerative colitis patients with an interest in participating in MODULATE. If the self-screening indicates potential eligibility, then patients can contact their local participating site to begin the recruitment process.


Keep up to date with all things MODULATE with recent news articles, other media and an insight into our live Twitter feed… Ran by Team MODULATE at the University of Leeds CTRU, regular updates are posted on our page and displayed here, too!

Meet the Team

The MODULATE trial has been designed and coordinated by a range of people from different backgrounds, who all have an interest in discovering new and safe treatments for patients with Ulcerative Colitis. Each of our team members have provided invaluable advice developed over years of experience within their specialist areas.

For Sites

This page is for the MODULATE investigators, to access additional trial documentation and key updates in the running of MODULATE at your site. Please contact the MODULATE inbox for login details.

Icons made by Freepik from