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In ACT4 the aim is to find out the best way to treat patients with early cancer of the anus (in tumours up to 5 cm). An early cancer is one that is relatively small and has not spread anywhere else.

The study is comparing 2 different doses of radiotherapy given with chemotherapy (chemoradiotherapy).

The aim is to explore if giving less radiotherapy is as good as the standard dose at treating anal cancer whilst reducing the side effects of the treatment.

ACT4 Recruitment

163 patients – recruitment closed 01/12/2020

Trial Results

The early results of the trial are available here: PLATO trial results