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The ACT5 study is looking at the best way to treat patients with locally advanced cancer of the anus.A more advanced anal cancer is one that is a little larger (bigger than 4cm) and/or may have spread to local lymph nodes.

The study is comparing 3 different doses of radiotherapy given with chemotherapy (chemoradiotherapy).

The study is exploring if giving a higher dose of radiotherapy is better than the standard dose at treating locally advanced anal cancer and reducing the chance of it coming back whilst not causing too many extra side effects.

ACT5 Recruitment

463 patients – recruitment closed 31/08/2023